tm testpack plus strep on-board controls  (Abbott Laboratories)

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Summary of findings table

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques: Diagnostic Assay, Enzyme Immunoassay, Selection, Significance Assay

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Acceava Strep A (Biostar).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: ACON Strep A Rapid Test Strip.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques: Stripping Membranes

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: BioNexia Strep A (BioMerieux).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: CARDS QS Strep A (Quidel).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Clearview Exact Strep A.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Clearview Strep A.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Diaquick Strep A Test (Dialab).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Direct Strep A EIA.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: IM Strep A (International Microbio).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: OSOM Strep A (Genzyme).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: OSOM Ultra Strep A (Genzyme).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: QuickVue Dipstick Strep A (Quidel).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: QuickVue Flex Strep A (Quidel).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: QuickVue In‐Line Strep A (Quidel).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: QuickVue+ Strep A (Quidel).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: SD Bioline Strep A.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Signify Strep A (Abbott).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Strep A Abon kit.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Strep A OIA (Biostar).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Strep A OIA Max (Biostar).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Strep A Rapid Test Device.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Strep A Sign.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Strep A test II (INTEX Diagnostica).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: SureScreen Test Strep A.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: TestPack Strep A (Abbott).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: TestPack Plus (Abbott).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: TestPack Plus Strep A with OBC II (Abbott).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Ventrescreen Strep A (Ventrex Lab).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Visuwell Strep A (ADI).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Icon Strep A.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Link 2 Strep A Rapid Test (Becton Dickinson).

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Event Test Strip Strep A.

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques: Stripping Membranes

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Data tables by test

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques: Stripping Membranes

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet:

Article Snippet: No Open in a separate window Cohen 1988 Study characteristics Patient sampling Cross‐sectional study Prospective design Sample: unclear Direct comparison of different RADTs: no Direct comparison of several throat culture techniques: no Person performing the throat sample: physician Exclusion if recent antibiotics use before inclusion: yes (within 7 days before inclusion) Clinical selection of patients: implicit criteria (see below) Presenting signs and symptoms: acute pharyngitis or tonsillitis with dysphagia or fever Age range for inclusion: 4 to 15 years Patient characteristics and setting Sample size: 563 Age (distribution): not reported GAS prevalence according to culture (with 95% confidence interval): 21.5% (95% CI not reported) Country of study: France Sex (% of girls): not reported Clinical severity assessment: none Clinical setting: office‐based Multi‐centre study Index tests Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA Target condition and reference standard(s) Throat culture medium: inhibitory Atmosphere of incubation: anaerobic Duration of incubation: 48 hours GAS confirmation: latex test Number of plates inoculated: 1 Assessment of GAS antibody response: no Relevant details: ‐ Flow and timing No follow‐up Comparative Type of study Journal article (in French) Notes The study was supported by ASTRA laboratories Methodological quality Item Authors' judgement Risk of bias Applicability concerns DOMAIN 1: Patient Selection Was a consecutive or random sample of patients enrolled?

Techniques: Immuno Assay, Enzyme-linked Immunosorbent Assay

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: TestPack Plus Strep A with OBC II (Abbott).

Article Snippet: 41 TestPack Plus Strep A with OBC II (Abbott) Open in a separate window Test 41 TestPack Plus Strep A with OBC II (Abbott). , 1 , 454.

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Data tables by test

Article Snippet: 41 TestPack Plus Strep A with OBC II (Abbott) Open in a separate window Test 41 TestPack Plus Strep A with OBC II (Abbott). , 1 , 454.

Techniques: Comparison, Stripping Membranes

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Data extracted from each study

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques: Selection, Comparison, Incubation

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Methodological quality assessment table for each study

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques: Selection, Incubation

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Forest plots of RADT sensitivity and specificity for GAS detection, ordered by commercial kit. TP = True Positive; FP = False Positive; FN = False Negative; TN = True Negative.

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Summary ROC plot of RADT sensitivity and specificity for GAS detection (n = 105). Each individual study cohort is represented by an empty circle. The filled circle is the pooled summary estimate for sensitivity and specificity. The solid curve represents the 95% confidence region around the summary estimate; the dashed curve represents the 95% prediction region.

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Summary ROC plot of RADT sensitivity and specificity for GAS detection: EIA (n = 86) versus OIA (n = 19). The filled black circle is the pooled summary estimate for sensitivity and specificity of EIA tests; the filled red circle is the pooled summary estimate for sensitivity and specificity of OIA tests The solid curves represent the 95% confidence region around the summary estimate; the dashed curves represent the 95% prediction region.

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Summary ROC plot of RADT sensitivity and specificity for GAS detection: direct comparison of EIA versus OIA (n = 2). Each individual study cohort is represented by an empty black circle (EIA) and an empty red diamond (OIA), connected by a dotted line.

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques: Comparison

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Summary of findings table

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques: Diagnostic Assay, Enzyme Immunoassay, Biomarker Discovery, Selection, Comparison, Significance Assay

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: TestPack Strep A (Abbott).

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: TestPack Plus (Abbott).

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: TestPack Plus Strep A with OBC II (Abbott).

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques:

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet: Data tables by test

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques: Comparison, Stripping Membranes

Journal: The Cochrane Database of Systematic Reviews

Article Title: Rapid antigen detection test for group A streptococcus in children with pharyngitis

doi: 10.1002/14651858.CD010502.pub2

Figure Lengend Snippet:

Article Snippet: Index tests , Throat swab: 2 different (first one for the RADT, second one only if RADT+) Commercial name of the RADT: TestPack Plus Strep A (Abbott) Type of RADT: EIA , , .

Techniques: Immuno Assay, Enzyme-linked Immunosorbent Assay